Synonyms for CYP enzymes

Annotators' home

CYP450 annotators' page

Many CYP450 enzymes are known by a number of names that don't include "cyp" or "450" or "cytochrome". We are trying to list them so you can tag them as cyp when you see them. Here's a start, thanks to Dalal. The codes in brackets refer to source and synonym set: all the terms marked "[NCI-1]" are listed in the NCI metathesaurus as synonyms, and so on.

I've removed the names that contain "cytochrome" or "cyp" or "P450", since those are obvious. But I've kept some of them in a list at the bottom of this page to illustrate the variety of ways that even these self-labeling names can be structured.

Some of the listed synonyms, taken straight from authoritative references, are trivial spelling variations:

Steroid 11beta hydroxylase Cytochrome P-450(scc) cholesterol monooxygenase
(side-chain cleaving)

Steroid 11-beta-Hydroxylase Cytochrome P450scc cholesterol monooxygenase
(side-chain-cleaving)

The Enzyme Commission has a standardized system of numeric identifiers and recommended names for enzymes. Below is a list of the codes they list as belonging to CYP450 enzymes. The corresponding recommended names are in the list immediately below.

Non-obvious Synonyms
Non-synonyms
A note on "activity"
Enzyme Commission Codes
Some self-labeling Synonyms
Sources

Non-obvious Synonyms

(-)-limonene 3-monooxygenase [EC] (-)-limonene 6-monooxygenase [EC] (-)-limonene 7-monooxygenase [EC] (benzo(a)pyrene) hydroxylase [SK*, NCI] (S)-canadine synthase [EC] (S)-cheilanthifoline synthase [EC] (S)-stylopine synthase [EC] 1 alpha, 25-dihydroxycholecalciferol-24-hydroxylase [NCI-3] 1 alpha, 25-dihydroxyvitamin D(3)-24-hydroxylase [NCI-3] 1 alpha-hydroxyvitamin D3 25-hydroxylase [NCI-5] 1, 25-DC-24-hydroxylase [NCI-3] 1, 25-dihydroxyvitamin D3 24-hydroxylase [NCI-3] 1-hydroxycholecalciferol 25-hydroxylase [NCI-5] 1-hydroxyvitamin D3 25-hydroxylase [NCI-5] 1-OH-D3 25-hydroxylase [NCI-5] 11 beta-Hydroxylase [NCI-1] 11 beta-hydroxylase [SK*, NCI] 16 alpha-hydroxylase [SK*, NCI] 17 alpha-hydroxylase [SK*, NCI] 17,20-lyase [NCI] 1alpha-hydroxylase (CYP1alpha) [SK*, Google] 20,22-Desmolase [NCI-4] 21-hydroxylase [SK*, NCI] 25(OH) vitamin D-24-hydroxylase [NCI-3] 25-HC-24-hydroxylase [NCI-3] 25-hydroxy vitamin D2 24-hydroxylase [NCI-3] 25-hydroxycholecalciferol 23-hydroxylase [NCI-3] 25-hydroxycholecalciferol-24-hydroxylase [NCI-3] 25-hydroxylase [RC*, NCI] 25-hydroxyvitamin D (3)-24-hydroxylase [NCI-3] 25-hydroxyvitamin D (3)-24R-hydroxylase [NCI-3] 25-hydroxyvitamin D 23-hydroxylase [NCI-3] 25-hydroxyvitamin D3 23-hydroxylase [NCI-3] 25-hydroxyvitamin D3-1 alpha-hydroxylase[SK*, NCI] 25-OH-D3 23-hydroxylase [NCI-3] 27-hydroxycholesterol 7alpha-monooxygenase [EC] 3,9-dihydroxypterocarpan 6a-monooxygenase [EC] 4-Nitrophenol-2-Hydroxylase [SK*, NCI] 5 beta-cholestane-3 alpha,7 alpha-diol 26-hydroxylase [NCI-5] 5 beta-cholestane-3-alpha,7 alpha-diol 27-monooxygenase [NCI-5] 5-beta cholestane-3 alpha,7 alpha,12 alpha-triol 27-monooxygenase [NCI-5] 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase [NCI-5] 7 ethoxyresorufin O-deethylase [RC*, NCI] 7-benzyloxyresorufin O-dealkylase [SK*, NCI] 7-deoxyloganin 7-hydroxylase [EC] 7-pentylresorufin O-depentylase [SK*, NCI] acetanilide 4-hydroxylase [SK*] alkane 1-monooxygenase [EC] androstenedione aromatase [NCI-2] aniline 4-hydroxylase [RC*, NCI] aniline hydroxylase [NS*, NCI] aromatase [NCI-2] aryl hydrocarbon hydroxylase [SK*] benzo[a]pyrene 3-hydroxylase [CW*, NCI] benzoate 4-monooxygenase [EC] benzphetamine N-demethylase [RC*, NCI] benzyloxyresorufin O-dealkylase [SK*, NCI] berbamunine synthase [EC] BROD [SK*, NCI] C-triol 27-hydroxylase [NCI-5] C27-steroid 26-hydroxylase [NCI-5] calcidiol 1-monooxygenase [EC] calcitriol 24-hydroxylase [NCI-3] camphor 5-monooxygenase [EC] cholecalciferol-25-hydroxylase [NCI-5] cholestanetriol 26-hydroxylase [NCI-5] cholestanetriol 26-monooxygenase [EC, NCI-5] cholesterol 26-hydroxylase [NCI-5] cholesterol 27-hydroxylase [NCI-5] cholesterol 7 alpha-hydroxylase [NCI] cholesterol 7alpha-monooxygenase [EC] cholesterol desmolase [NCI-4] cholesterol monooxygenase (side-chain cleaving) [NCI-4, EC] cholesterol side-chain cleavage enzyme [NCI-4] cholesterol, reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving) [NCI-4] corticosterone 18-monooxygenase [EC] Corticosterone 6 beta-hydroxylase [SK*] coumarin 7-hydroxylase [RC*, NCI] cytochrome P-450 steroid 27-hydroxylase [NCI-5] cytochrome P-450 sterol 26-hydroxylase [NCI-5] debrisoquine 4-hydroxylase (Cytochrome P450 2D6) [SK*] debrisoquine Hydroxylase (Cytochrome P450 2D6) [SK*] DHC 27-monooxygenase [NCI-5] dihydrochelirubine 12-monooxygenase [EC] dihydrosanguinarine 10-monooxygenase [EC] Ecdysone 20 hydroxylase [=CYP6H1; NS*, Google] ecdysone 20-monooxygenase [EC] ent-kaurene oxidase [EC] ent-kaurenoic acid oxidase [EC] erythromycin N demethylase [= CYP3A; NS*, NCI] estrogen synthase [NCI-2] estrogen synthetase [NCI-2] fatty acid hydroxylase [= CYP94A5; NS, from textual context] flavonoid 3'-monooxygenase [EC] heme-thiolate [SK*, Google] hydroperoxide dehydratase [EC] hydroxycholesterol 25-hydroxylase [NCI-5] hydroxyphenylacetonitrile 2-monooxygenase [EC] imipramine 2-hydroxylase (Cytochrome P450 2D6) [SK*] isoflavone 2'-hydroxylase [EC] isoflavone 3'-hydroxylase [EC] lanosterol 14 alpha-methyl demethylase [NS*] laurate hydroxylase [RC*, NCI] Lauric acid omega hydroxylase [RC*, NCI] leukotriene B4 omega-hydroxylase [RC*, NCI] leukotriene-B4 20-monooxygenase [EC] linalool 8-monooxygenase [EC] LTB4 omega-hydroxylase [RC*, NCI] mephenytoin 4-hydroxylase (CYP2C19) [SK*] mephenytoin hydroxylase [=CYP2C19; NS*, NCI] methyltetrahydroprotoberberine 14-monooxygenase [EC] N-methylcoclaurine 3'-monooxygenase [EC] nifedipine oxidase (P450 3A4) [SK*] nitrosodimethylamine N-demethylase [RC*,] p-nitrophenol hydroxylase (CYP2E1) [SK*, Google] pacitaxel 6alpha-hydroxylase [= CYP2C8; NS, from textual context] PBD-1 (P450-PBD-1 or cytochrome P450 3A12 (canine)) [SK*] pentoxyresorufin O-dealkylase [SK*, NCI] phenacetin O-dealkylase [= CYP1A2; NS*, NCI] phenacetin O-deethylase [NS, from textual context, SK*, Google] PROD [SK*, NCI] progesterone 21-Hydroxylase [SK*, NCI] prostacyclin synthase (CYP8A1) [SK*] prostaglandin-I synthase [EC] protopine 6-monooxygenase [EC] RA 18 hydroxylase [NS, from textual context] RA 4 hydroxylase [= cytochrome P450 4 hydroxylase; NS*, NCI] retinoic acid 4-hydroxylase (CYP26A1)[SK*, NCI] S-mephenytoin 4'-hydroxylase (CYP2C9) [SK*] salidroside mono-oxygenase [SK*] salutaridine synthase [EC] steroid 11 hydroxylase CYP 11B1 [NCI-1] steroid 11beta hydroxylase [NCI-1] also: steroid 11-beta-hydroxylase steroid 11beta monooxygenase [NCI-1] steroid 11beta-monooxygenase [EC] steroid 17-alpha-monooxygenase [SK*, NCI] steroid 17alpha-monooxygenase [EC] steroid 21-monooxygenase [EC] steroid 21-monooxygenase [SK*, NCI] steroid 25-hydroxylase [NCI-5] steroid 27-hydroxylase [NCI-5] steroid hydroxylases[SK*, NCI] steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating) [NCI-1] sterol 14-demethylase [EC] sterol 26-hydroxylase [NCI-5] sterol 27-hydroxylase [NCI-5] tabersonine 16-hydroxylase [EC] taxane 10beta-hydroxylase [EC] taxane 13alpha-hydroxylase [EC] testosterone 16 alpha-hydroxylase [SK*, NCI] Testosterone 7 alpha hydroxylase [RC*, NCI] THC 27-monooxygenase [NCI-5] thromboxane-A synthase [EC] tolbutamide hydroxylase [= CYP2C8/9; NS*, Google] trans-cinnamate 4-monooxygenase [EC] tyrosine N-monooxygenase [EC] unspecific monooxygenase [EC] vinorine hydroxylase [EC] vitamin D 24-hydroxylase [NCI-3] vitamin D-25-hydroxylase [SK*, NCI] vitamin D2 25-hydroxylase [NCI-5] vitamin D3 25-hydroxylase [NCI-5] vitamin D3-25-hydroxylase [SK*, NCI]

Non-synonyms

Once you start recognizing non-obvious synonyms for CYP450 enzymes, you will start noticing some names that look similar to known non-obvious synonyms but which actually are not names of CYP450s. Here are a few:

R warfarin hydroxylase (a CYP inhibitor) warfarin-7-hydroxylase (CYP2C9 Gene)

A note on "activity"

Many abstracts talk about measuring "XYZ activity" or "XYZ hydroxylase activity". Strictly speaking, they are not measuring the level of XYZ or XYZ hydroxylase, but in practical terms this is how the enzymes we are interested in are often measured. "In any P450 citation, when hydroxylation activity is mentioned, it is referring to CYP." This is part of the discussion in the e-mail archive:

The following terms for CYP and substances show up in this abstract:

1 alpha-hydroxyvitamin D-3 **
1 alpha-Hydroxyvitamin D-3 25-hydroxylase *
1,25-dihydroxyvitamin D-3 **
25-hydroxylase *
vitamin D-3 25-hydroxylase *

When they are talking about "hydroxylase" they are talking about CYP, otherwise they are referring to the substrate the enzyme is acting on.

As a result of this discussion we determined that
* these terms ending in "hydroxylase" should be tagged as CYP450
** the other terms in this list should be tagged as Substance

Enzyme Commission Codes

These will usually be preceded by EC: "EC 1.14.13.13".

1.3.3.9 1.14.13.30 1.14.13.53 1.14.13.74 1.14.15.3 1.14.21.5

1.14.13.11 1.14.13.37 1.14.13.55 1.14.13.75 1.14.15.4 1.14.99.9

1.14.13.12 1.14.13.41 1.14.13.56 1.14.13.76 1.14.15.5 1.14.99.10

1.14.13.13 1.14.13.42 1.14.13.57 1.14.13.77 1.14.15.6 1.14.99.22

1.14.13.15 1.14.13.47 1.14.13.60 1.14.13.78 1.14.21.1 1.14.99.28

1.14.13.17 1.14.13.48 1.14.13.70 1.14.13.79 1.14.21.2 4.2.1.92

1.14.13.21 1.14.13.49 1.14.13.71 1.14.14.1 1.14.21.3 5.3.99.4

1.14.13.28 1.14.13.52 1.14.13.73 1.14.15.1 1.14.21.4 5.3.99.5

A Sampling of Self-labeling Synonyms

24-hydroxylase cytochrome P-450 [NCI-3] CYP 11A1 [NCI-4] CYP 19 [NCI-2] CYP11A1 [NCI-4] CYP11B1 [NCI-1] CYP19 [NCI-2] CYP19 Protein [NCI-2] CYP24 [NCI-3] cytochrome P-450 CYP11A1 [NCI-4] cytochrome P-450 CYP11B1 [NCI-1] cytochrome P-450 CYP19 [NCI-2] cytochrome P-450(11 beta) [NCI-1] cytochrome P-450(AROM) [NCI-2] cytochrome P-450(scc) [NCI-4] cytochrome P450 11A1 [NCI-4] cytochrome P450 11B1 [NCI-1] cytochrome P450 19 [NCI-2] cytochrome P450(24) [NCI-3] cytochrome P450cc24 [NCI-3] cytochrome P450scc [NCI-4] P450AROM [NCI-2]

Sources

NCI-n: NCI Metathesaurus
EC: SwissProt: Directory of P450-containing Systems: II. EC numbers for P450 enzymes (Degtyarenko)
initials + *: found by an annotator